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KMID : 1033620110380010031
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Clinical and Experimental Reproductive Medicine
2011 Volume.38 No. 1 p.31 ~ p.36
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Does blastomere biopsy in preimplantation genetic diagnosis affect early serum β-hCG levels?
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Cho Yeon-Jean
Kim Jin-Yeong
Song In-Ok
Lee Hyung-Song
Lim Chun-Kyu
Koong Mi-Kyoung
Kang Inn-Soo
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Abstract
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Objective: To determine whether the serum β-human chorionic gonadotropin (hCG) profile following preimplantation genetic diagnosis (PGD) is lower than that of intracytoplasmic sperm injection (ICSI) cycles.
Methods: A total of 129 PGD cycles and 1,161 age-matched ICSI cycles, which resulted in pregnancy (serum β-hCG≥5 mIU/mL) on post-ovulation day (POD) 12 were included. We compared the mean serum β-hCG levels on POD 12, 14, 21, and 28, doubling time of serum hCG, and created a cut-off value for predicting a singleton pregnancy in each group.
Results: The mean serum β-hCG concentration of the PGD group was significantly lower than that of the control group on POD 12, 14, and 21. The doubling time of serum β-hCG at each time interval showed no significant difference. The cut-off-value of serum β-hCG for predicting a single viable pregnancy was 32.5 mIU/mL on POD 12 and 113.5 mIU/mL on POD 14 for the PGD group, which was lower than that for the control group.
Conclusion: Blastomere biopsy may decrease the β-hCG-producing activity of the trophoblasts, especially in early pregnancy. Setting a lower cut-off value of serum β-hCG for predicting pregnancy outcomes in PGD may be needed.
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KEYWORD
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Preimplantation Genetic Diagnosis, Human Chorionic Gonadotropin, Blastomeres, Biopsy, Pregnancy Outcome, Human
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